Calverley P M, Leggett R J, Flenley D C
Br Med J (Clin Res Ed). 1981 Oct 3;283(6296):878-80. doi: 10.1136/bmj.283.6296.878.
The effects of carbon monoxide on exercise tolerance as assessed by the distance walked in 12 minutes were studied in 15 patients with severe chronic bronchitis and emphysema (mean forced expiratory volume in one second 0.56 1, mean forced vital capacity 1.54 1). Each subject walked breathing air and oxygen before and after exposure to sufficient carbon monoxide to raise their venous carboxyhaemoglobin concentration by 9%. There was a significant reduction in the walking distance when the patients breathed air after exposure to carbon monoxide (p less than 0.01), and the significant increase in walking distance seen after exercise when breathing oxygen at 2 1/minute via nasal cannulae was abolished if carbon monoxide has previously been administered. Thus concentrations of carboxyhaemoglobin frequently found in bronchitic patients who smoke may reduce their tolerance of everyday exercise, possibly by interfering with the transport of oxygen to exercising muscles.
在15例重度慢性支气管炎和肺气肿患者（一秒钟用力呼气量平均为0.56升，用力肺活量平均为1.54升）中，研究了一氧化碳对运动耐力的影响，运动耐力通过12分钟内行走的距离来评估。在每个受试者吸入足以使其静脉血中碳氧血红蛋白浓度升高9%的一氧化碳之前和之后，分别在呼吸空气和氧气的状态下行走。暴露于一氧化碳后呼吸空气时，患者的行走距离显著缩短（p<0.01），如果之前已给予一氧化碳，那么通过鼻导管以每分钟2升的速度吸氧运动后所观察到的行走距离显著增加的情况就会消失。因此，吸烟的支气管炎患者中常见的碳氧血红蛋白浓度可能会降低他们对日常运动的耐受力，这可能是通过干扰氧气向运动肌肉中的运输来实现的。
