Effect of topical application of amino acids on gastric pepsin secretion in the rat. Part II: effect of pH changes and glycine in separate perfusion preparation.

Gastric acid and pepsin were measured in antrum and fundus separately by perfusing each region of the stomach in anaesthetized rats. Perfusion of the antral region with alkaline and acid solutions did not affect gastric acid and pepsin secretions in the fundic gland region. Gastric secretions in the antrum and acid secretions in the fundus remained unchanged when each region of the stomach was instillated with glycine. Pepsin stimulation was observed in the fundic region only when perfused with glycine. We confirmed our previous observation that topical amino acid in the oxyntic gland stimulated pepsin secretion directly. The pepsin stimulatory effect of amino acid was found to be independent of antral regulation.