雌激素受体分析在早期乳腺癌中的长期预后意义
The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast.
作者信息
Winstanley J, Cooke T, George W D, Murray G, Holt S, Croton R, Griffiths K, Nicholson R
机构信息
Department of Surgery Liverpool, Institute for Cancer Research, Cardiff, U.K.
出版信息
Br J Cancer. 1991 Jul;64(1):99-101. doi: 10.1038/bjc.1991.249.
Abstract
The long term prognostic significance of oestrogen receptors was assessed in a prospective study of 767 patients presenting between the years 1975 and 1981 with stage 1 and 2 breast cancer treated by mastectomy with either full axillary dissection or nodal sampling. Oestrogen receptor binding was determined by a dextran coated charcoal method and median follow up was 11 years. Oestrogen receptors were present in 396 (54%) of tumours. Absence of oestrogen receptors was associated with tumours of high histological grade, but there was no relationship between nodal status or tumour size. Oestrogen receptor status did not predict survival for the group as a whole or when stratified by nodal status. In multivariate analysis both nodal status and tumour size were powerful independent prognostic factors, but oestrogen receptors failed to achieve statistical significance.
摘要
在一项前瞻性研究中，对1975年至1981年间接受乳房切除术（伴腋窝淋巴结清扫或淋巴结取样）治疗的767例Ⅰ期和Ⅱ期乳腺癌患者，评估了雌激素受体的长期预后意义。采用葡聚糖包被活性炭法测定雌激素受体结合情况，中位随访时间为11年。396例（54%）肿瘤存在雌激素受体。雌激素受体缺失与高组织学分级肿瘤相关，但与淋巴结状态或肿瘤大小无关。雌激素受体状态不能预测整个组或按淋巴结状态分层时的生存率。在多变量分析中，淋巴结状态和肿瘤大小都是强大的独立预后因素，但雌激素受体未达到统计学显著性。
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