Yoshimura H, Nakamura M, Koeda T, Yoshikawa K
Mutat Res. 1981 Sep;90(1):49-55. doi: 10.1016/0165-1218(81)90049-5.
Carbadox and olaquindox were examined for mutagenicities in the repair tests with Bacillus subtilis (rec assay) and Salmonella typhimurium (uvr assay) and in the reverse mutation test (TA100 and TA98 of S. typhimurium). Both compounds were positive in the rec and uvr assays, and were highly mutagenic for strains TA100 and TA98. Carbadox was about 6 times move mutagenic than olaquindox in the absence of S9 mix. When incubated in S9 mix or bacterial cytosol (BC) mix for various times at 37 degree C, carbadox was found to lose its mutagenic activities easier than olaquindox. The mutagenicity of carbadox was almost inactivated at 10 min after incubation with S9 mix, but olaquindox still retained its activities even at 20 min. While carbadox required 20 min to be inactivated in BC mix, olaquindox was not completely inactivated even if incubated for 60 min.
对卡巴氧和喹乙醇进行了检测，以评估其在枯草芽孢杆菌修复试验（rec检测）和鼠伤寒沙门氏菌修复试验（uvr检测）以及反向突变试验（鼠伤寒沙门氏菌TA100和TA98）中的致突变性。两种化合物在rec和uvr检测中均呈阳性，并且对TA100和TA98菌株具有高度致突变性。在不存在S9混合液的情况下，卡巴氧的致突变性比喹乙醇高约6倍。当在37℃下于S9混合液或细菌胞质溶胶（BC）混合液中孵育不同时间时，发现卡巴氧比喹乙醇更容易丧失其致突变活性。卡巴氧与S9混合液孵育10分钟后致突变性几乎失活，但喹乙醇即使在孵育20分钟后仍保留其活性。虽然卡巴氧在BC混合液中需要20分钟才能失活，但喹乙醇即使孵育60分钟也未完全失活。
