Niranjan B G, Bhat N K, Avadhani N G
Science. 1982 Jan 1;215(4528):73-5. doi: 10.1126/science.6797067.
Administration of the hepatic carcinogen aflatoxin B1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B1 on the mitochondrial genetic system.
给实验动物施用肝脏致癌物黄曲霉毒素B1后，其与肝脏线粒体DNA的共价结合浓度比核DNA高3至4倍。即使在24小时后，线粒体DNA中致癌物加合物的浓度仍保持不变，这可能是由于缺乏切除修复。同样，线粒体转录和翻译在长达24小时内仍受到抑制，这表明黄曲霉毒素B1对线粒体遗传系统有长期影响。
