Applebaum R S, Marth E H
Mycopathologia. 1981 Nov 11;76(2):103-14. doi: 10.1007/BF00443757.
Aflatoxin B2 is a secondary metabolite produced by the ubiquitous molds Aspergillus flavus and Aspergillus parasiticus. The toxin was first characterized in 1963 as the etiological agent responsible for the infamous "Turkey X' disease. Since that time, much information on its chemistry, toxicity and biological activity has accumulated. A significant amount of work has been done to elucidate its biosynthesis. Evidence indicates the polyketide route as its point of origin. The steps involved in the polyketide pathway, the six identified intermediated compounds, and the experimental techniques and analytical instrumentation used to procure information on aflatoxin biogenesis are included in this review.
黄曲霉毒素B2是由无处不在的霉菌黄曲霉和寄生曲霉产生的次生代谢产物。该毒素于1963年首次被鉴定为导致臭名昭著的“火鸡X病”的病原体。从那时起，关于其化学、毒性和生物活性的大量信息不断积累。人们已经开展了大量工作来阐明其生物合成过程。有证据表明聚酮途径是其起源。本综述涵盖了聚酮途径所涉及的步骤、六种已鉴定的中间化合物，以及用于获取黄曲霉毒素生物合成信息的实验技术和分析仪器。
