Buchanan R L, Jones S B, Stahl H G
Eastern Regional Research Center, USDA, Philadelphia, PA 19118.
Mycopathologia. 1987 Dec;100(3):135-44. doi: 10.1007/BF00437039.
At 5 microM, miconazole prevented the growth of Aspergillus parasiticus Speare in a number of media. Sensitivity to miconazole was increased approximately 10-fold in a medium containing glycerol. At sub-inhibitory concentrations, miconazole stimulated aflatoxin synthesis on media which normally support toxin formation. Miconazole inhibited respiration and altered mitochondrial ultrastructure, suggesting that miconazole inhibits growth and stimulates aflatoxin production by depressing mitochondrial activity.
在5微摩尔浓度下，咪康唑可抑制寄生曲霉Speare在多种培养基中的生长。在含有甘油的培养基中，对咪康唑的敏感性增加了约10倍。在亚抑制浓度下，咪康唑可刺激通常支持毒素形成的培养基上的黄曲霉毒素合成。咪康唑抑制呼吸作用并改变线粒体超微结构，这表明咪康唑通过抑制线粒体活性来抑制生长并刺激黄曲霉毒素的产生。
