另一个吸烟危害：血清IgE浓度升高及职业性过敏风险增加。
Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy.
作者信息
Zetterström O, Osterman K, Machado L, Johansson S G
出版信息
Br Med J (Clin Res Ed). 1981 Nov 7;283(6301):1215-7. doi: 10.1136/bmj.283.6301.1215.
Abstract
Individual smoking histories of a general population sample and of two groups of workers exposed to occupational allergens were related to serum IgE concentrations and results of radioallergosorbent and prick tests in the workers. The geometric mean IgE concentration was higher in smokers than in non-smokers. The distribution of serum IgE values in the two groups showed an apparent difference, with a bimodal appearance in the smokers. Evidence of sensitisation against occupational allergens was more common in workers who smoked. The adjuvant effect of smoking on IgE antibody production might be due to damage to airways mucosa and supports the mucosal theory of atopy.
摘要
对一般人群样本以及两组接触职业过敏原的工人的个人吸烟史，与这些工人的血清IgE浓度以及放射变应原吸附试验和点刺试验结果进行了关联分析。吸烟者的几何平均IgE浓度高于非吸烟者。两组血清IgE值的分布存在明显差异，吸烟者呈双峰分布。吸烟工人对职业过敏原的致敏证据更为常见。吸烟对IgE抗体产生的佐剂作用可能是由于气道黏膜受损，这支持了特应性的黏膜理论。
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