Pandey R C, Toussaint M W, Stroshane R M, Kalita C C, Aszalos A A, Garretson A L, Wei T T, Byrne K M, Geoghegan R F, White R J
J Antibiot (Tokyo). 1981 Nov;34(11):1389-401. doi: 10.7164/antibiotics.34.1389.
A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described.
