Strauss D, Fleck W
Z Allg Mikrobiol. 1975;15(8):615-23.
A Streptomyces strain belonging to Streptomyces griseus (Krainsky) Waksman et Henrici 1948 sensu Hütter (1967) was found to produce the red-pigment antibiotic leukaemomycin. The antitumor active antibiotic was isolated from the culture broth and purified by ion-exchange processes. The crude base of leukaemomycin mainly consists of 4 components with biological activity. The base-complex was separated by counter-current distribution into the biological active leukaemomycins B1, B2, C, and D. The single components of leukaemomycin were compared with the anthracycline antibiotics daunomycin, dihydrodaunomycin, and adriamycin. The analytical procedures allowed to state the identity of leukaemomycin B1 with rubomycin B, leukaemomycin C with daunomycin, leukaemomycin D with dihydrodaunomycin and allowed to suggest the identity of leukaemomycin B2 with daunosaminyldaunomycin. Formulas and physicochemical data are given. Bio-assay methods are described to determine leukaemomycin B complex beside leukaemomycin C.
发现一株属于1948年（克拉因斯基）瓦克斯曼和亨利西氏的灰色链霉菌（按胡特1967年的定义）的链霉菌菌株能产生红色素抗生素白血病霉素。从培养液中分离出这种具有抗肿瘤活性的抗生素，并通过离子交换法进行纯化。白血病霉素的粗碱主要由4种具有生物活性的成分组成。通过逆流分配法将碱复合物分离成具有生物活性的白血病霉素B1、B2、C和D。将白血病霉素的单一组分与蒽环类抗生素柔红霉素、二氢柔红霉素和阿霉素进行了比较。分析程序确定了白血病霉素B1与鲁博霉素B相同，白血病霉素C与柔红霉素相同，白血病霉素D与二氢柔红霉素相同，并推测白血病霉素B2与道诺胺基柔红霉素相同。给出了分子式和理化数据。描述了除白血病霉素C外测定白血病霉素B复合物的生物测定方法。
