霍奇金病中里德-施特恩伯格细胞及其他细胞IgG的免疫组化显示
Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease.
作者信息
Garvin A J, Spicer S S, Parmley R T, Munster A M
出版信息
J Exp Med. 1974 May 1;139(5):1077-83. doi: 10.1084/jem.139.5.1077.
Abstract
Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.
摘要
为进行最佳免疫细胞化学检测而轻度固定的脾脏和淋巴结，或为手术诊断而常规处理的脾脏和淋巴结，在无肿瘤区域的众多免疫细胞中显示出对IgG的强烈选择性免疫染色。此外，霍奇金病累及的区域在里德-施特恩伯格细胞中显示出对IgG的强烈免疫染色，但对IgM无染色，在霍奇金细胞中也显示出弱阳性至强阳性染色。在超微结构上，里德-施特恩伯格细胞和霍奇金细胞显示出丰富的多核糖体和稀疏的颗粒内质网，并且似乎在未结合的核糖体上形成了无法输出的IgG。
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Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease.霍奇金病中里德-施特恩伯格细胞及其他细胞IgG的免疫组化显示
J Exp Med. 1974 May 1;139(5):1077-83. doi: 10.1084/jem.139.5.1077.
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