接受环孢素A和类固醇治疗的儿童的肝移植和肾移植
Liver and kidney transplantation in children receiving cyclosporin A and steroids.
作者信息
Starzl T E, Iwatsuki S, Malatack J J, Zitelli B J, Gartner J C, Hakala T R, Rosenthal J T, Shaw B W
出版信息
J Pediatr. 1982 May;100(5):681-6. doi: 10.1016/s0022-3476(82)80564-7.
Abstract
The new immunosuppressive agent, cyclosporin A, was used with low doses of steroids to treat eight patients undergoing hepatic transplantation and three patients undergoing cadaveric renal transplantation. Seven of the eight liver recipients are well, including one who was given two livers. The three kidney recipients who had developed cytotoxic antibodies after previously rejecting grafts with conventional immunosuppressive therapy, have had good results despite conditions which usually preclude attempts at transplantation. The ability to control rejection effectively and safely without chronic high-dose steroid therapy may make the described therapeutic regimen valuable for pediatric recipients of whole organs.
摘要
新型免疫抑制剂环孢素A与低剂量类固醇联合使用，用于治疗8例接受肝移植的患者和3例接受尸体肾移植的患者。8例肝移植受者中有7例情况良好，其中1例接受了两个肝脏。3例肾移植受者在先前使用传统免疫抑制疗法排斥移植物后产生了细胞毒性抗体，尽管存在通常会妨碍移植尝试的情况，但仍取得了良好效果。在不进行慢性高剂量类固醇治疗的情况下有效且安全地控制排斥反应的能力，可能使所描述的治疗方案对小儿全器官受者具有重要价值。
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