Stöcklin E, Gudat F, Bianchi L, Schmid M, Stalder G A
Schweiz Med Wochenschr. 1982 Apr 12;112(15):521-3.
Among 571 liver biopsies delta-Ag was found in 10 of 365 HBsAg positive patients (9 with CAH, 1 with CPH). Delta-Ag was demonstrated in nuclei and cytoplasm of liver cells in both cryostat and paraffin sections. Follow-up studies revealed persistence of delta-Ag for as long as 6 years and temporary appearance or loss of Dane particle-associated parameters without a change in the concomitant inflammation. These findings are compatible with the hypothesis that delta-Ag represents a defective viral agent which modulates, by superinfection, the typical viral expression patterns of HBV infection.
在571例肝活检中，365例HBsAg阳性患者中有10例检测到δ抗原（9例为慢性活动性肝炎，1例为慢性迁延性肝炎）。在冰冻切片和石蜡切片中均在肝细胞的细胞核和细胞质中证实有δ抗原。随访研究显示δ抗原持续存在长达6年，同时 Dane 颗粒相关参数有短暂出现或消失，但伴随的炎症无变化。这些发现与以下假说相符，即δ抗原代表一种缺陷病毒因子，它通过重叠感染来调节HBV感染的典型病毒表达模式。
