Decaux G, Waterlot Y, Genette F, Hallemans R, Demanet J C
Br Med J (Clin Res Ed). 1982 Jul 10;285(6335):89-90. doi: 10.1136/bmj.285.6335.89.
Seven out of nine patients with chronic inappropriate secretion of antidiuretic hormone were successfully treated with 40 mg frusemide daily. One patient needed 80 mg, and the remaining patient achieved only a small increase in diuresis after 40 mg frusemide; this was probably related to his low creatinine clearance. In order to maintain a salt intake high enough to compensate for the loss of urine electrolytes 3 to 6 g sodium chloride was added as tablets to the sodium-free diet in six patients. Hypokalaemia occurred in five patients but was easily corrected with either supplements of potassium chloride or a potassium-sparing diuretic. These findings add further weight to evidence that Frusemide is a good alternative for the treatment of patients with inappropriate secretion of antidiuretic hormone who cannot tolerate water restriction.
9例抗利尿激素分泌异常综合征患者中，7例患者通过每日服用40mg速尿成功治愈。1例患者需要80mg速尿，其余1例患者在服用40mg速尿后尿量仅略有增加；这可能与他较低的肌酐清除率有关。为了维持足够高的盐摄入量以补偿尿电解质的流失，6例患者在无钠饮食中添加了3至6g氯化钠片剂。5例患者出现低钾血症，但通过补充氯化钾或保钾利尿剂很容易得到纠正。这些发现进一步证明，对于不能耐受限水治疗的抗利尿激素分泌异常综合征患者，速尿是一种很好的替代治疗药物。
