Gilat T, Ben Hur H, Gelman-Malachi E, Terdiman R, Peled Y
Gut. 1978 Jul;19(7):602-5. doi: 10.1136/gut.19.7.602.
The hydrogen breath test was performed by ingestion of 20 g lactulose and analysis of end-expiratory air. Eighteen patients undergoing colonoscopy, 17 receiving antibiotics, 12 prepared for colon surgery, and 15 controls were examined. The test was repeated under control conditions in the treated patients. Eleven of 55 subjects failed to produce significant amounts of hydrogen under control conditions. This 20% proportion of non-hydrogen producers is much higher than that reported by other investigators. The hydrogen production was very markedly depressed after preparation for colonscopy and antibiotic therapy. The effect of neomycin and enemata as used in preparation for colon surgery was less marked. Hydrogen production by the colonic flora is thus subject to individual variations and may be affected by various therapeutic regimens. All these may cause false negative results when using the hydrogen breath test to evaluate carbohydrate absorption. The test should therefore not be performed for a considerable time after therapeutic manipulation of the colonic flora.
通过摄入20克乳果糖并分析呼气末气体来进行氢呼气试验。对18例接受结肠镜检查的患者、17例接受抗生素治疗的患者、12例为结肠手术做准备的患者以及15名对照者进行了检查。在对照条件下对接受治疗的患者重复进行该试验。55名受试者中有11名在对照条件下未能产生大量氢气。这20%的非氢气产生者比例远高于其他研究者报告的比例。在为结肠镜检查做准备和进行抗生素治疗后，氢气产生非常明显地受到抑制。用于结肠手术准备的新霉素和灌肠剂的作用则不太明显。因此，结肠菌群产生氢气的情况存在个体差异，并且可能受到各种治疗方案的影响。在使用氢呼气试验评估碳水化合物吸收时，所有这些情况都可能导致假阴性结果。因此在对结肠菌群进行治疗性操作后的相当长一段时间内不应进行该试验。
