Rennard S I, Stier L E, Crystal R G
J Invest Dermatol. 1982 Jul;79 Suppl 1:77s-82s. doi: 10.1111/1523-1747.ep12545844.
The intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy.
新合成胶原蛋白的细胞内降解是一种细胞途径，在分泌之前，它可导致多种细胞类型合成的胶原蛋白有10% - 60%被破坏。该途径可起到调节作用，限制缺陷分子的分泌，并响应某些细胞外介质，调节分泌的胶原蛋白的数量和类型。此外，该途径可能导致包括纤维化、糖尿病和坏血病在内的多种影响细胞外基质疾病的发病机制。
