Mindt W, Eberhard P, Schäfer R
Biotelem Patient Monit. 1982;9(1):28-35.
The methodology of cutaneous PCO2 measurement and the results of the first clinical studies performed with a newly developed sensor are reported. The in vitro data of the sensor are: sensitivity 55 mV/decade; response time tau 90% = 50 s; drift less than 10% per 24 h; no measurable interference by oxygen and anesthetic gases. At a sensor temperature of 44 degrees C, the correlation between arterial PCO2 and cutaneous PCO2 is significant, with correlation coefficients above 0.95 both in case of neonates and adult patients. The cutaneous PCO2 is, however, consistently higher than arterial PCO2, and a correction of the cutaneous PCO2 value needs to be performed. At 44 degrees C, the time lag between changes of cutaneous PCO2 and arterial PCO2 is about 2-3 min as estimated from capnometric measurements. At lower sensor temperatures, the correlation between arterial and cutaneous PCO2 is still good; however, the physiological response time of the cutaneous PCO2 measurement becomes prohibitively long.
报告了皮肤二氧化碳分压（PCO2）测量方法以及使用新开发的传感器进行的首批临床研究结果。该传感器的体外数据如下：灵敏度55 mV/十倍变化；响应时间τ90% = 50秒；每24小时漂移小于10%；不受氧气和麻醉气体的可测量干扰。在传感器温度为44℃时，新生儿和成年患者的动脉PCO2与皮肤PCO2之间的相关性显著，相关系数均高于0.95。然而，皮肤PCO2始终高于动脉PCO2，因此需要对皮肤PCO2值进行校正。在44℃时，根据二氧化碳波形图测量估计，皮肤PCO2和动脉PCO2变化之间的时间滞后约为2 - 3分钟。在较低的传感器温度下，动脉和皮肤PCO2之间的相关性仍然良好；然而皮肤PCO2测量的生理响应时间变得过长。
