Heymann D L, Smith E L, Nakano J H, Jato J G, Martin G E, Maben G K
Br Med J (Clin Res Ed). 1982 Aug 21;285(6341):531-3. doi: 10.1136/bmj.285.6341.531.
Two of the more heat-stable measles vaccines were field tested in Cameroon. Both maintained the minimum required infectivity titre and the ability to induce seroconversion after storage unreconstituted at 37 degrees C for 14 days. One of the vaccines, studied after reconstitution, maintained its ability to induce seroconversion after reconstitution and storage at 25 degrees C for 48 hours and at 37 degrees C for at least four hours. The increased heat stability of the studied vaccines will not eliminate the need for a well-monitored system of vaccine conservation and distribution but will ease the rigid cold-storage requirements of conventional measles vaccines.
两种热稳定性更高的麻疹疫苗在喀麦隆进行了现场测试。在37摄氏度未复溶保存14天后，两种疫苗均保持了最低要求的感染性滴度以及诱导血清转化的能力。其中一种疫苗在复溶后进行研究，在25摄氏度复溶并保存48小时以及在37摄氏度保存至少4小时后，仍保持诱导血清转化的能力。所研究疫苗热稳定性的提高不会消除对一个监测良好的疫苗保存和分发系统的需求，但将缓解传统麻疹疫苗严格的冷藏要求。
