尼日利亚儿童中麻疹疫苗的血清转化率较低。
Low seroconversion rates to measles vaccine among children in Nigeria.
作者信息
Adu F D, Akinwolere O A, Tomori O, Uche L N
机构信息
College of Medicine, University of Ibadan, Nigeria.
出版信息
Bull World Health Organ. 1992;70(4):457-60.
The Nigerian Expanded Programme on Immunization (EPI) was assessed with particular reference to measles immunization. Of 150 children who received measles vaccine at the Institute of Child Health, University of Ibadan, Nigeria, 82 (54.7%) seroconverted. The immune response was directly related to the titre of the vaccines used. Vaccines whose titres were 10(-1) to 10(1.7) stimulated immune responses in 0-25% of vaccinees, those with titres in the range 10(-2.1) to 10(-2.5) stimulated responses in 12-47.6%, while those with titres of 10(-2.7) to 10(-3.4) stimulated responses in 87.5-100% of vaccinees. Only one of the vaccines used had a titre that met the minimum WHO required standard of log 10(-3) TCID50 at the point of vaccination.
对尼日利亚扩大免疫规划（EPI）进行了评估，特别提及了麻疹免疫情况。在尼日利亚伊巴丹大学儿童健康研究所接种麻疹疫苗的150名儿童中，82名（54.7%）出现了血清转化。免疫反应与所用疫苗的效价直接相关。效价为10（-1）至10（1.7）的疫苗在0 - 25%的接种者中刺激产生免疫反应，效价在10（-2.1）至10（-2.5）范围内的疫苗在12 - 47.6%的接种者中刺激产生反应，而效价为10（-2.7）至10（-3.4）的疫苗在87.5 - 100%的接种者中刺激产生反应。所用疫苗中只有一种在接种时的效价达到了世界卫生组织规定的最低标准log 10（-3）TCID50 。
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