Galey D, Jaffard R
Laboratoire de Neurosciences Comportementales et Cognitives, Université de Bordeaux I, Talence, France.
Neurosci Lett. 1992 Aug 31;143(1-2):87-90. doi: 10.1016/0304-3940(92)90239-4.
The experiment reported here was designed to highlight the effects of medial septal nucleus electrical stimulation on memory processes. To that end, we have used a learning task carried out in a 4-hole board in which animals were successively presented with the location of 2 baited holes. Under these conditions, the consequence of a weak stimulation (30 microA peak to peak, 80 s in duration) applied 30 s after acquisition of these 2 separate spatial informations was assessed on a retention test 24 h later. The results indicated that performance of stimulated animals was improved by medial septal stimulation as shown by an increase in the time duration of exploration of the second previously baited hole. However, post-training stimulation also produced a significant avoidance of the first previously baited hole not observed in the control groups. These results suggest that medial septal stimulation improves retroactive inhibition involved in working memory processes, thus leading to better retention of this kind of learning situation.
本文所报道的实验旨在突出内侧隔核电刺激对记忆过程的影响。为此，我们采用了在四孔板上进行的学习任务，在此任务中，动物会依次被呈现出两个有诱饵的孔的位置。在这些条件下，在获取这两个独立的空间信息30秒后施加微弱刺激（峰峰值30微安，持续80秒），并在24小时后的记忆测试中评估其结果。结果表明，内侧隔刺激改善了受刺激动物的表现，表现为对第二个先前有诱饵的孔的探索时间增加。然而，训练后刺激也导致对第一个先前有诱饵的孔产生显著回避，而对照组未观察到这种情况。这些结果表明，内侧隔刺激改善了工作记忆过程中涉及的逆向抑制，从而导致对这种学习情境的更好保留。
