Luksza A R
Br J Dis Chest. 1982 Jan;76(1):15-9.
Sixty patients with acute severe asthma were treated by conventional methods in all respects except for the use of steroids. Patients who were not currently taking systemic steroids (30) received none during the severe attack, and those who were currently taking systemic steroids (30) were given 400 mg hydrocortisone daily. The results were compared to a further group of 30 patients with acute severe asthma of similar severity who were treated in the same hospital by the same methods but with much larger doses of hydrocortisone (1200 mg daily). All 60 patients recovered and the time course, changes in heart rate and peak expiratory flow (PEFR) were similar in all groups. These results suggest that steroids are of doubtful value in the treatment of acute severe asthma and further randomized and controlled trials are required.
60例急性重症哮喘患者接受了除使用类固醇外各方面的常规治疗。目前未服用全身性类固醇的患者（30例）在重症发作期间未接受任何类固醇治疗，而目前正在服用全身性类固醇的患者（30例）每天给予400毫克氢化可的松。将结果与另外一组30例病情严重程度相似的急性重症哮喘患者进行比较，这组患者在同一家医院接受相同方法治疗，但使用剂量大得多的氢化可的松（每天1200毫克）。所有60例患者均康复，且所有组的病程、心率变化和呼气峰值流速（PEFR）相似。这些结果表明，类固醇在急性重症哮喘治疗中的价值存疑，需要进一步进行随机对照试验。
