Francke U, De Martinville B, D'Eustachio P, Ruddle F H
Cytogenet Cell Genet. 1982;33(3):267-71. doi: 10.1159/000131769.
We have mapped the genes for murine immunoglobulin lambda light chains to the region of chromosome 16 proximal to band B5 by hybridizing a cDNA probe for gamma light chains to the DNA of a series of hybrid clones made between mouse fibroblasts carrying Searle's translocation, T(X;16)16H, and Chinese hamster cells. Based on homology, we predict that the human Ig gamma gene (IGL) will map to the proximal two-thirds of HSA 22.
我们通过将γ轻链的cDNA探针与一系列由携带Searle易位T(X;16)16H的小鼠成纤维细胞和中国仓鼠细胞构建的杂交克隆的DNA杂交，已将小鼠免疫球蛋白λ轻链基因定位到16号染色体上靠近B5带的近端区域。基于同源性，我们预测人类Igγ基因（IGL）将定位到人类22号染色体的近端三分之二区域。
