比较基因定位：小鼠λ轻链基因位于小鼠16号染色体B5中心区域，该区域与人类21号染色体不同源。
Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21.
作者信息
Francke U, De Martinville B, D'Eustachio P, Ruddle F H
出版信息
Cytogenet Cell Genet. 1982;33(3):267-71. doi: 10.1159/000131769.
PMID:6813029
Abstract
We have mapped the genes for murine immunoglobulin lambda light chains to the region of chromosome 16 proximal to band B5 by hybridizing a cDNA probe for gamma light chains to the DNA of a series of hybrid clones made between mouse fibroblasts carrying Searle's translocation, T(X;16)16H, and Chinese hamster cells. Based on homology, we predict that the human Ig gamma gene (IGL) will map to the proximal two-thirds of HSA 22.
摘要
我们通过将γ轻链的cDNA探针与一系列由携带Searle易位T(X;16)16H的小鼠成纤维细胞和中国仓鼠细胞构建的杂交克隆的DNA杂交，已将小鼠免疫球蛋白λ轻链基因定位到16号染色体上靠近B5带的近端区域。基于同源性，我们预测人类Igγ基因（IGL）将定位到人类22号染色体的近端三分之二区域。
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