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1
Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.编码小鼠免疫球蛋白λ轻链的结构基因的染色体定位。小鼠λ轻链的遗传学。
J Exp Med. 1981 Apr 1;153(4):793-800. doi: 10.1084/jem.153.4.793.
2
Localization of the murine lambda 5 gene on chromosome 16.小鼠λ5基因在16号染色体上的定位。
Genomics. 1987 Nov;1(3):277-9. doi: 10.1016/0888-7543(87)90055-3.
3
Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21.比较基因定位：小鼠λ轻链基因位于小鼠16号染色体B5中心区域，该区域与人类21号染色体不同源。
Cytogenet Cell Genet. 1982;33(3):267-71. doi: 10.1159/000131769.
4
Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes.人类κ和λ免疫球蛋白轻链恒定区基因的染色体定位。
J Exp Med. 1982 May 1;155(5):1480-90. doi: 10.1084/jem.155.5.1480.
5
Somatic variants of murine immunoglobulin lambda light chains.小鼠免疫球蛋白λ轻链的体细胞变体
Nature. 1982 Jul 22;298(5872):380-2. doi: 10.1038/298380a0.
6
Arrangement of lambda light chain genes in mutant clones of the MOPC 315 mouse myeloma cells.MOPC 315小鼠骨髓瘤细胞突变克隆中λ轻链基因的排列
J Immunol. 1982 Jul;129(1):260-6.
7
The breakpoint of the Philadelphia chromosome 22 in chronic myeloid leukaemia is distal to the immunoglobulin lambda light chain constant region genes.慢性髓细胞白血病中费城染色体22的断点位于免疫球蛋白λ轻链恒定区基因的远端。
Mol Biol Med. 1983 Jul;1(1):11-9.
8
Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.在产生小鼠λ链的B细胞中，κ链恒定区基因的缺失涉及到与V-J连接相似的染色体内DNA重组。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6211-5. doi: 10.1073/pnas.82.18.6211.
9
Restricted association of V and J-C gene segments for mouse lambda chains.小鼠λ链V和J-C基因片段的限制性组合
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2484-8. doi: 10.1073/pnas.81.8.2484.
10
Lambda light chain constant and variable gene complements in wild-derived inbred mouse strains.野生来源近交系小鼠品系中的λ轻链恒定区和可变区基因互补情况。
Eur J Immunol. 1985 Jun;15(6):535-40. doi: 10.1002/eji.1830150602.

引用本文的文献

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Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.小鼠DNA依赖性蛋白激酶催化亚基的基因定位于严重联合免疫缺陷（scid）位点。
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10792-5. doi: 10.1073/pnas.92.23.10792.
2
Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.3-甲基胆蒽诱导的小鼠肉瘤肿瘤特异性抗原的染色体定位
J Exp Med. 1981 Sep 1;154(3):964-77. doi: 10.1084/jem.154.3.964.
3
Autoimmune diseases: immunopathology and etiopathogenesis.自身免疫性疾病：免疫病理学与病因发病机制
Am J Pathol. 1982 Sep;108(3):319-65.
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DNA sequence associated with chromosome translocations in mouse plasmacytomas.与小鼠浆细胞瘤中染色体易位相关的DNA序列。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6622-6. doi: 10.1073/pnas.79.21.6622.
5
Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.免疫球蛋白表达的等位基因排斥并非由体细胞分离所致。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):606-7. doi: 10.1073/pnas.79.2.606.
6
The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.编码肌肉收缩蛋白、肌球蛋白重链、肌球蛋白轻链2和骨骼肌肌动蛋白的基因位于三条不同的小鼠染色体上。
EMBO J. 1982;1(11):1299-305. doi: 10.1002/j.1460-2075.1982.tb01314.x.
7
Localization of the casein gene family to a single mouse chromosome.酪蛋白基因家族在小鼠单条染色体上的定位。
J Cell Biol. 1982 Apr;93(1):199-204. doi: 10.1083/jcb.93.1.199.
8
Characterization of superoxide dismutase (SOD-1 and SOD-2) activities in inbred mice: evidence for quantitative variability and possible nonallelic SOD-1 polymorphism.近交系小鼠中超氧化物歧化酶（SOD-1和SOD-2）活性的特征：数量变异性及可能的非等位基因SOD-1多态性的证据
Biochem Genet. 1983 Apr;21(3-4):349-64. doi: 10.1007/BF00499144.
9
Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.小鼠T细胞杂交瘤和T淋巴瘤中免疫球蛋白重链基因的重排与转录
Proc Natl Acad Sci U S A. 1982 May;79(9):3015-9. doi: 10.1073/pnas.79.9.3015.
10
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes.小鼠λ轻链免疫球蛋白基因连接区的DNA序列。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):530-3. doi: 10.1073/pnas.79.2.530.

本文引用的文献

1
Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.编码小鼠免疫球蛋白重链的结构基因簇的染色体定位。
J Exp Med. 1980 Jun 1;151(6):1545-50. doi: 10.1084/jem.151.6.1545.
2
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.对小鼠免疫球蛋白重链基因和血清前白蛋白基因的连锁分析确定了它们在12号染色体上的位置，该位置靠近12F1带中的T(5;12)31H断点。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):550-3. doi: 10.1073/pnas.77.1.550.
3
Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315).一种小鼠骨髓瘤蛋白（MOPC - 315）轻链的氨基酸序列。
Biochemistry. 1973 Dec 18;12(26):5400-16.
4
Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.小鼠轻链可变区标记与胸腺细胞表面抗原的遗传相关性。
J Exp Med. 1974 Nov 1;140(5):1432-7. doi: 10.1084/jem.140.5.1432.
5
Mouse lambda-chain sequences.小鼠λ链序列。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2112-6. doi: 10.1073/pnas.70.7.2112.
6
Nucleotide sequence of the rightward operator of phage lambda.噬菌体λ右向操纵基因的核苷酸序列。
Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8. doi: 10.1073/pnas.72.3.1184.
7
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.通过使用硫酸葡聚糖将大的DNA片段从琼脂糖凝胶高效转移至重氮苄氧基甲基纸并进行快速杂交。
Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683-7. doi: 10.1073/pnas.76.8.3683.
8
Stable association of the human transgenome and host murine chromosomes demonstrated with trispecific microcell hybrids.利用三特异性微细胞杂种证明人类转基因组与宿主小鼠染色体的稳定关联。
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3937-41. doi: 10.1073/pnas.74.9.3937.
9
Molecular analysis of chromosome-mediated gene transfer.染色体介导的基因转移的分子分析
Proc Natl Acad Sci U S A. 1979 Aug;76(8):3987-90. doi: 10.1073/pnas.76.8.3987.
10
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis.通过体细胞遗传分析确定的小鼠基因组中的单纯疱疹病毒1整合位点。
Cell. 1978 Oct;15(2):455-68. doi: 10.1016/0092-8674(78)90015-6.

编码小鼠免疫球蛋白λ轻链的结构基因的染色体定位。小鼠λ轻链的遗传学。

Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.

作者信息

D'Eustachio P, Bothwell A L, Takaro T K, Baltimore D, Ruddle F H

出版信息

J Exp Med. 1981 Apr 1;153(4):793-800. doi: 10.1084/jem.153.4.793.

DOI:10.1084/jem.153.4.793
PMID:6265582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186131/
Abstract

To determine the chromosomal localization of murine lambda light (L) chain structural genes, DNA from a panel of 11 mouse x hamster somatic cell hybrids was scored for the presence of sequences homologous to cloned lambda DNA probe molecules. Six of the hybrids had detectable lambda I and lambda II gene sequences. In all six, the full complement of murine sequences was present, and in its germline configuration. The remaining hybrids lacked any detectable murine lambda L chain gene sequences. The only mouse chromosome present in all of the positive hybrids and absent from the negative ones was number 16, allowing the assignment of lambda L chain structural genes to this chromosome. Together with the previous assignments of the kappa L chain genes to chromosome 6 and heavy chain genes to chromosome 12, this finding completes the mapping of Ig structural genes in the mouse at the chromosomal level.

摘要

为确定小鼠λ轻（L）链结构基因的染色体定位，对一组11个小鼠×仓鼠体细胞杂种的DNA进行检测，以寻找与克隆的λDNA探针分子同源的序列。其中6个杂种含有可检测到的λI和λII基因序列。在所有这6个杂种中，完整的小鼠序列均存在，且呈种系构型。其余杂种未检测到任何小鼠λL链基因序列。所有阳性杂种中均存在而阴性杂种中均不存在的唯一小鼠染色体是16号染色体，从而将λL链结构基因定位于此染色体。连同先前将κL链基因定位于6号染色体以及重链基因定位于12号染色体的结果，这一发现完成了小鼠免疫球蛋白结构基因在染色体水平上的图谱绘制。