将大肠杆菌K-12暴露于DNA损伤剂可诱导L-丝氨酸脱氨酶活性。
L-Serine deaminase activity is induced by exposure of Escherichia coli K-12 to DNA-damaging agents.
作者信息
Newman E B, Ahmad D, Walker C
出版信息
J Bacteriol. 1982 Nov;152(2):702-5. doi: 10.1128/jb.152.2.702-705.1982.
Abstract
The synthesis of L-serine deaminase in Escherichia coli K-12 was induced after exposure of cells to a variety of DNA-damaging agents, including UV irradiation, nalidixic acid, and mitomycin C. Synthesis was also induced during growth at high temperature. A mutant constitutive for SOS functions showed an elevated level of L-serine deaminase activity. The response to DNA-damaging agents thus may be mediated via the SOS system.
摘要
将大肠杆菌K-12细胞暴露于多种DNA损伤剂（包括紫外线照射、萘啶酸和丝裂霉素C）后，可诱导L-丝氨酸脱氨酶的合成。在高温生长过程中也会诱导合成。一个SOS功能组成型突变体显示L-丝氨酸脱氨酶活性水平升高。因此，对DNA损伤剂的反应可能是通过SOS系统介导的。
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