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1
L-Serine deaminase activity is induced by exposure of Escherichia coli K-12 to DNA-damaging agents.将大肠杆菌K-12暴露于DNA损伤剂可诱导L-丝氨酸脱氨酶活性。
J Bacteriol. 1982 Nov;152(2):702-5. doi: 10.1128/jb.152.2.702-705.1982.
2
Identification of the uvrD gene product of Escherichia coli as DNA helicase II and its induction by DNA-damaging agents.鉴定大肠杆菌的uvrD基因产物为DNA解旋酶II及其受DNA损伤剂的诱导。
J Biol Chem. 1984 Feb 10;259(3):1560-5.
3
Expression of the dnaN and dnaQ genes of Escherichia coli is inducible by mitomycin C.大肠杆菌的dnaN和dnaQ基因的表达可被丝裂霉素C诱导。
Mol Gen Genet. 1989 Oct;219(1-2):187-92. doi: 10.1007/BF00261175.
4
Occurrence of alkali-labile sites in pulse labelled DNA of Escherichia coli after the action of DNA-damaging chemicals.
Folia Microbiol (Praha). 1987;32(6):531-4. doi: 10.1007/BF02877202.
5
[Intensification of the bactericidal action of mitomycin C and of UV irradiation with some anthracycline antibiotics].
Antibiotiki. 1976 Sep;21(9):798-800.
6
Beta subunit of DNA polymerase III holoenzyme is induced upon ultraviolet irradiation or nalidixic acid treatment of Escherichia coli.DNA聚合酶III全酶的β亚基在大肠杆菌经紫外线照射或萘啶酸处理后被诱导产生。
Mutat Res. 1994 Jul 1;308(1):53-64. doi: 10.1016/0027-5107(94)90198-8.
7
SOS independent survival against mitomycin C induced lethality in a rifampicin-nalidixic acid-resistant mutant of Escherichia coli.在利福平-萘啶酸抗性大肠杆菌突变体中，SOS 依赖的生存以抵抗丝裂霉素 C 诱导的致死性。
Mutat Res. 1988 Sep;194(2):109-20. doi: 10.1016/0167-8817(88)90013-2.
8
Weigle-reactivation in a cyanobacterium (Synechococcus PCC7934) is induced by UV but not by mitomycin-C or nalidixic acid.
Photochem Photobiol. 1988 Oct;48(4):473-5. doi: 10.1111/j.1751-1097.1988.tb02848.x.
9
[Genetic control of the protective effect of spermidine in Escherichia coli cells as affected by mitomycin C].[亚精胺对丝裂霉素C作用下大肠杆菌细胞保护效应的遗传控制]
Genetika. 1983 Jun;19(6):888-96.
10
Measurement of recA protein induction in Salmonella typhimurium: a possible biochemical test for the detection of DNA damaging agents.
Biochimie. 1982 Aug-Sep;64(8-9):775-81. doi: 10.1016/s0300-9084(82)80128-4.

引用本文的文献

1
Use of an inducible regulatory protein to identify members of a regulon: application to the regulon controlled by the leucine-responsive regulatory protein (Lrp) in Escherichia coli.利用可诱导调节蛋白鉴定调节子成员：应用于大肠杆菌中由亮氨酸应答调节蛋白（Lrp）控制的调节子
J Bacteriol. 1997 Oct;179(20):6254-63. doi: 10.1128/jb.179.20.6254-6263.1997.
2
The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.亮氨酸响应调节蛋白，大肠杆菌新陈代谢的全局调节因子。
Microbiol Rev. 1994 Sep;58(3):466-90. doi: 10.1128/mr.58.3.466-490.1994.
3
A mutation in Escherichia coli K-12 results in a requirement for thiamine and a decrease in L-serine deaminase activity.大肠杆菌K-12中的一种突变导致对硫胺素的需求以及L-丝氨酸脱氨酶活性降低。
J Bacteriol. 1985 Jan;161(1):272-6. doi: 10.1128/jb.161.1.272-276.1985.
4
In vitro and in vivo activation of L-serine deaminase in Escherichia coli K-12.大肠杆菌K-12中L-丝氨酸脱氨酶的体外和体内激活
J Bacteriol. 1985 Jun;162(3):1270-5. doi: 10.1128/jb.162.3.1270-1275.1985.
5
L-serine degradation in Escherichia coli K-12: cloning and sequencing of the sdaA gene.大肠杆菌K-12中L-丝氨酸的降解：sdaA基因的克隆与测序
J Bacteriol. 1989 Sep;171(9):5095-102. doi: 10.1128/jb.171.9.5095-5102.1989.
6
Elevated serine catabolism is associated with the heat shock response in Escherichia coli.丝氨酸分解代谢增强与大肠杆菌中的热休克反应相关。
J Bacteriol. 1989 May;171(5):2619-25. doi: 10.1128/jb.171.5.2619-2625.1989.

本文引用的文献

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Induced formation of serine and threonine deaminases by Escherichia coli.大肠杆菌诱导丝氨酸和苏氨酸脱氨酶的形成。
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Purified lexA protein is a repressor of the recA and lexA genes.纯化的LexA蛋白是recA和LexA基因的阻遏物。
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In vitro studies on L-serine deaminase activity of Escherichia coli K12.大肠杆菌K12的L-丝氨酸脱氨酶活性的体外研究。
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L-serine degradation in Escherichia coli K-12: directly isolated ssd mutants and their intragenic revertants.大肠杆菌K-12中L-丝氨酸的降解：直接分离的ssd突变体及其基因内回复突变体
J Bacteriol. 1982 May;150(2):710-5. doi: 10.1128/jb.150.2.710-715.1982.
5
Serine utilization by Klebsiella aerogenes.产气克雷伯菌对丝氨酸的利用
J Bacteriol. 1981 May;146(2):647-55. doi: 10.1128/jb.146.2.647-655.1981.
6
A mutation affecting L-serine and energy metabolism in E. coli K12.大肠杆菌K12中一种影响L-丝氨酸和能量代谢的突变。
Mol Gen Genet. 1981;182(1):143-7. doi: 10.1007/BF00422781.
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Ultraviolet reactivation and ultraviolet mutagenesis of lambda in different genetic systems.λ噬菌体在不同遗传系统中的紫外线复活和紫外线诱变
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Studies on L-serine deaminase in Escherichia coli K-12.大肠杆菌K-12中L-丝氨酸脱氨酶的研究
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Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.大肠杆菌中的紫外线诱变与诱导性DNA修复
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10
Factors influencing the in vivo stability of L-serine deaminase activity in E. coli K12.影响大肠杆菌K12中L-丝氨酸脱氨酶活性体内稳定性的因素。
Can J Microbiol. 1978 Dec;24(12):1607-13. doi: 10.1139/m78-257.

将大肠杆菌K-12暴露于DNA损伤剂可诱导L-丝氨酸脱氨酶活性。

L-Serine deaminase activity is induced by exposure of Escherichia coli K-12 to DNA-damaging agents.

作者信息

Newman E B, Ahmad D, Walker C

出版信息

J Bacteriol. 1982 Nov;152(2):702-5. doi: 10.1128/jb.152.2.702-705.1982.

DOI:10.1128/jb.152.2.702-705.1982
PMID:6813312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC221519/
Abstract

The synthesis of L-serine deaminase in Escherichia coli K-12 was induced after exposure of cells to a variety of DNA-damaging agents, including UV irradiation, nalidixic acid, and mitomycin C. Synthesis was also induced during growth at high temperature. A mutant constitutive for SOS functions showed an elevated level of L-serine deaminase activity. The response to DNA-damaging agents thus may be mediated via the SOS system.

摘要

将大肠杆菌K-12细胞暴露于多种DNA损伤剂（包括紫外线照射、萘啶酸和丝裂霉素C）后，可诱导L-丝氨酸脱氨酶的合成。在高温生长过程中也会诱导合成。一个SOS功能组成型突变体显示L-丝氨酸脱氨酶活性水平升高。因此，对DNA损伤剂的反应可能是通过SOS系统介导的。