大肠杆菌K-12中的一种突变导致对硫胺素的需求以及L-丝氨酸脱氨酶活性降低。
A mutation in Escherichia coli K-12 results in a requirement for thiamine and a decrease in L-serine deaminase activity.
作者信息
Newman E B, Miller B, Colebrook L D, Walker C
出版信息
J Bacteriol. 1985 Jan;161(1):272-6. doi: 10.1128/jb.161.1.272-276.1985.
Abstract
Mutants of Escherichia coli K-12 deficient in L-serine deaminase (L-SD) activity have been isolated. These strains required thiamine and grew normally when it was provided. The decrease in L-SD activity caused no obvious metabolic deficiency. A study of revertants and transductants showed that a single mutation was responsible for the thiamine requirement and for the decrease in L-SD activity.
摘要
已分离出缺乏L-丝氨酸脱氨酶（L-SD）活性的大肠杆菌K-12突变体。这些菌株需要硫胺素，当提供硫胺素时能正常生长。L-SD活性的降低未引起明显的代谢缺陷。对回复突变体和转导子的研究表明，单个突变导致了对硫胺素的需求以及L-SD活性的降低。
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