黑腹果蝇一个包含乙醇脱氢酶结构基因的常染色体小区域的遗传学。III. 影响无毛基因表达的亚效和超效突变。
The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless.
作者信息
Ashburner M
出版信息
Genetics. 1982 Jul-Aug;101(3-4):447-59. doi: 10.1093/genetics/101.3-4.447.
Abstract
A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak suppressor of H. Confirming Nash (1970), deletions of l(2)br7 are dominant suppressors, and duplications are dominant enhancers of H. A simple model is proposed to account for the interaction of l(2)br7 and H, assuming that amorphic (or hypomorphic) alleles of l(2)br7 suppress H and that hypermorphic alleles enhance H.
摘要
在黑腹果蝇2L染色体臂上靠近乙醇脱氢酶（Adh）的位置，鉴定出一个致死位点（l(2)br7;35B6 - 10），它与普伦基特的无毛（H）显性抑制因子相关。在八个新等位基因中，七个作为H的显性抑制因子起作用，第八个是H的显性增强因子。其中一个抑制因子等位基因既是渗漏致死基因，也是H的弱抑制因子。证实了纳什（1970年）的研究，l(2)br7的缺失是H的显性抑制因子，重复则是H的显性增强因子。提出了一个简单模型来解释l(2)br7和H的相互作用，假设l(2)br7的无义（或亚效等位基因）抑制H，而超效等位基因增强H。
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