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X射线诱导影响黑腹果蝇乙醇脱氢酶水平的突变：无酶突变体的频率及遗传分析

X-ray-induced mutations affecting the level of the enzyme alcohol dehydrogenase in Drosophila melanogaster: frequency and genetic analysis of null-enzyme mutants.

作者信息

Aaron C S

出版信息

Mutat Res. 1979 Nov;63(1):127-37. doi: 10.1016/0027-5107(79)90109-x.

DOI:10.1016/0027-5107(79)90109-x
PMID:118372
Abstract

The frequency of X-ray-induced (null-enzyme) mutations at the alcohol dehydrogenase locus in Drosophila melanogaster was measured. The rate of recovery of chromosomes that fail to direct the synthesis of a functional Adh protein is 3 x 10(-8) per R for chromosomes that do not include large chromosome rearrangements. However, this analysis excludes a larger number of chromosomes that are "null-enzyme mutations" because thye are deleted for the region of the Adh locus. The dose of X-rays required to induce a frequency of non-deletion null-enzyme mutants equal to the spontaneous frequency is about 73 rad calculated from the data reported in this communication.

摘要

测定了X射线诱导的黑腹果蝇乙醇脱氢酶基因座（无酶）突变的频率。对于不包含大的染色体重排的染色体，未能指导功能性Adh蛋白合成的染色体的恢复率为每伦琴3×10⁻⁸。然而，该分析排除了大量因Adh基因座区域缺失而成为“无酶突变”的染色体。根据本通讯报道的数据计算，诱导非缺失无酶突变体频率等于自发频率所需的X射线剂量约为73拉德。

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