黑腹果蝇中丝氨酸-4转运RNA的剂量补偿
Dosage compensation of serine-4 transfer RNA in Drosophila melanogaster.
作者信息
Birchler J A, Owenby R K, Jacobson K B
出版信息
Genetics. 1982 Nov;102(3):525-37. doi: 10.1093/genetics/102.3.525.
Abstract
A dosage series of the X chromosome site for serine-4 transfer RNA consisting of one of three copies in females and one to two in males was constructed to test whether transfer RNA expression is governed by dosage compensation. A dosage effect on the level of the serine-4 isoacceptor was observed in both females and males when the structural locus was varied. However, in males, each dose had a relatively greater expression so the normal one dose was slightly greater than the total female value and the duplicated male had the highest relative expression of all the types examined. Serine-4 levels in males and females from an isogenic Oregon-R stock was similar. Thus the transfer RNA levels conform to the expectations of dosage compensation.
摘要
构建了一个与丝氨酸-4转运RNA的X染色体位点相关的剂量系列，雌性中有三个拷贝之一，雄性中有一到两个拷贝，以测试转运RNA的表达是否受剂量补偿的控制。当结构基因座发生变化时，在雌性和雄性中均观察到了对丝氨酸-4同功受体水平的剂量效应。然而，在雄性中，每个剂量的表达相对更高，因此正常的一个剂量略高于雌性的总量，而重复剂量的雄性在所有检测类型中具有最高的相对表达。来自同基因俄勒冈-R品系的雄性和雌性中的丝氨酸-4水平相似。因此，转运RNA水平符合剂量补偿的预期。
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