干扰花生四烯酸代谢的药物对人气道平滑肌反应性的影响
Modification of human airway smooth muscle reactivity by drugs that interfere with arachidonic acid metabolism.
作者信息
Adcock J J, Garland L G
出版信息
Br J Pharmacol. 1982 Dec;77(4):570-2. doi: 10.1111/j.1476-5381.1982.tb09333.x.
Abstract
Histamine-induced contractions of small airways from human lung were substantially augmented by the cyclo-oxygenase inhibitor, indomethacin, whereas the contraction of larger airways was not. Mixed cyclo-oxygenase/lipoxygenase inhibitors of arachidonic acid metabolism did not modify histamine-induced contractions of smooth muscle from either small or large airways but completely reversed the augmentation of histamine responses produced by indomethacin on the smaller airways. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, did not affect the augmentation of histamine-induced contractions by indomethacin.
摘要
组胺诱导的人肺小气道收缩，被环氧化酶抑制剂吲哚美辛显著增强，而大气道的收缩则未受影响。花生四烯酸代谢的环氧化酶/脂氧化酶混合抑制剂，对组胺诱导的小气道或大气道平滑肌收缩均无影响，但能完全逆转吲哚美辛对小气道组胺反应的增强作用。过敏反应慢反应物质（SRS-A）拮抗剂FPL55712，不影响吲哚美辛对组胺诱导收缩的增强作用。
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