Montie T C, Doyle-Huntzinger D, Craven R C, Holder I A
Infect Immun. 1982 Dec;38(3):1296-8. doi: 10.1128/iai.38.3.1296-1298.1982.
To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla mutant was isolated. An M-2 Fla spontaneous motile revertant was isolated from M-2 Fla. The three strains were biochemically and morphologically identical. Assay of Fla in the burned-mouse model showed a severe loss of virulence. The Fla revertant was fully virulent. The importance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.
为了测试鞭毛作为一种毒力因子的重要性，对强毒株铜绿假单胞菌M-2进行诱变，并分离出一个鞭毛（Fla）突变体。从M-2 Fla中分离出一个M-2 Fla自发运动回复体。这三种菌株在生化和形态上是相同的。在烧伤小鼠模型中对Fla的检测显示毒力严重丧失。Fla回复体具有完全的毒力。这表明了铜绿假单胞菌的运动性（鞭毛）在烧伤感染中的毒力方面的重要性。
