Jone C M, Trosko J E, Chang C, Fujiki H, Sugimura T
Gan. 1982 Dec;73(6):874-8.
Teleocidin, a mixture of teleocidin A and teleocidin B, was found to block metabolic cooperation between the 6-thioguanine-resistant and the 6-thioguanine-sensitive cells in the Chinese hamster V79 cell system. A teleocidin B preparation containing two isomers exerted the same effect. The dose-response curves of these two compounds were, in general, similar to that of 12-O-tetradecanoyl-phorbol-13-acetate, a powerful mouse skin tumor promoter. Upon hydrolysis with 6M hydrochloric acid containing 4% thioglycolic acid, teleocidin lost most of its ability to block metabolic cooperation. This was probably caused by the conformational change resulting from the rupture of the nine-membered lactam ring of teleocidin.
杀鱼菌素是杀鱼菌素A和杀鱼菌素B的混合物，发现在中国仓鼠V79细胞系统中，它能阻断6-硫鸟嘌呤抗性细胞和6-硫鸟嘌呤敏感细胞之间的代谢协同作用。一种含有两种异构体的杀鱼菌素B制剂也有同样的效果。这两种化合物的剂量反应曲线总体上与12-O-十四烷酰佛波醇-13-乙酸酯（一种强效的小鼠皮肤肿瘤促进剂）相似。用含4%巯基乙酸的6M盐酸水解后，杀鱼菌素丧失了大部分阻断代谢协同作用的能力。这可能是由于杀鱼菌素九元内酰胺环破裂导致的构象变化引起的。
