小鼠IgD在个体发育过程中的结构异质性。
Structural heterogeneity of murine IgD during ontogeny.
作者信息
Pollock R R, Mescher M F
出版信息
Mol Immunol. 1982 Dec;19(12):1535-40. doi: 10.1016/0161-5890(82)90264-4.
We have studied the expression of the two membrane delta heavy chains (delta 1 and delta 2) and the two native IgD structures (IgDI and IgDII) in neonatal mice. Both delta-chains appear simultaneously during development and neonatal mice, like adults, express equal amounts of delta 1 and delta 2. IgDI and IgDII also appear simultaneously during ontogeny and in the same ratio as expressed by adult mice of the same strain. Thus, when IgD first appears during ontogeny it shows the same structural heterogeneity as observed in adult mice.
我们研究了新生小鼠中两种膜δ重链（δ1和δ2）以及两种天然IgD结构（IgDI和IgDII）的表达情况。两种δ链在发育过程中同时出现，新生小鼠与成年小鼠一样，表达等量的δ1和δ2。IgDI和IgDII在个体发育过程中也同时出现，且比例与同品系成年小鼠相同。因此，当IgD在个体发育过程中首次出现时，它表现出与成年小鼠中观察到的相同的结构异质性。
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