Kung H F, Blau M
J Nucl Med. 1978 Aug;19(8):948-51.
The uptake of Tc-99m pyrophosphate was studied in rat myocardial lesions produced by a single subcutaneous injection of isoproterenol (10--50 mg/kg of body weight). The uptake in the whole heart of treated rats is directly proportional to the isoproterenol dose. The Tc-99m PPi uptake measured at various times after lesion initiation parallels the myocardial calcium concentration changes. This model is useful for screening radiopharmaceuticals, and may also be suitable for studying early uptake in myocardial infarcts.
通过皮下单次注射异丙肾上腺素（10 - 50毫克/千克体重）造成大鼠心肌损伤，研究了锝-99m焦磷酸盐的摄取情况。治疗大鼠全心脏的摄取量与异丙肾上腺素剂量成正比。损伤开始后不同时间测量的锝-99m焦磷酸盐摄取量与心肌钙浓度变化平行。该模型有助于筛选放射性药物，也可能适用于研究心肌梗死的早期摄取情况。
