Amiel D, Akeson W H, Harwood F L, Frank C B
Clin Orthop Relat Res. 1983 Jan-Feb(172):265-70.
The effects of intermediate-term immobilization on the medial collateral ligament (MCL) of the rabbit knee are profound. Immobilization causes atrophy with reduction of collagen mass and increased collagen degradation in th immobilized MCL. The matrix composition, as reflected by collagen turnover, changed dramatically as the period of immobilization was increased from nine to 12 weeks. Collagen degradation during these three additional weeks increases, as demonstrated by the fact that at 12 weeks, collagen degradation is 28% higher than that in controls, compared with 14% at nine weeks. Degradation, balanced by new collagen synthesis, produced very minor net decrease in total collagen mass (-2%) after nine weeks, but a large decrease in total collagen mass (-27%) is observed at the end of 12 weeks. Exponential degradation has occurred as immobilization has continued, and ligament regenerative capacity apparently has failed.
中期固定对兔膝关节内侧副韧带（MCL）的影响是深远的。固定会导致萎缩，固定的MCL中胶原蛋白量减少且胶原蛋白降解增加。随着固定时间从9周增加到12周，由胶原蛋白周转反映的基质组成发生了巨大变化。在这额外的三周中胶原蛋白降解增加，这一事实表明，在12周时，胶原蛋白降解比对照组高28%，而9周时为14%。降解由新的胶原蛋白合成平衡，9周后总胶原蛋白量仅有非常轻微的净减少（-2%），但在12周结束时观察到总胶原蛋白量大幅减少（-27%）。随着固定的持续，指数级降解已经发生，韧带的再生能力显然已经失效。
