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巨噬细胞活化选择性增强IgG2a的Fc受体表达。

Macrophage activation selectively enhances expression of Fc receptors for IgG2a.

作者信息

Ezekowitz R A, Bampton M, Gordon S

出版信息

J Exp Med. 1983 Feb 1;157(2):807-12. doi: 10.1084/jem.157.2.807.

DOI:10.1084/jem.157.2.807
PMID:6822787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186936/
Abstract

After infection with bacillus Calmette-Guérin, peritoneal macrophages (Mø) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mø by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mø. Selective enhancement of IgG2a FcR by Mø activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems.

摘要

感染卡介苗后，腹腔巨噬细胞（Mø）对单体和复合IgG2a的FcR表达增强，但对IgG2b则不然。FcR的同种型特异性可被免疫淋巴细胞因子在未激活的Mø上逆转，并且IgG2a免疫复合物是激活的Mø中呼吸爆发更有效的触发因素。Mø激活对IgG2a FcR的选择性增强可能解释了同源抗体在某些系统中介导细胞毒性的功效。

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Macrophage activation selectively enhances expression of Fc receptors for IgG2a.巨噬细胞活化选择性增强IgG2a的Fc受体表达。
J Exp Med. 1983 Feb 1;157(2):807-12. doi: 10.1084/jem.157.2.807.
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本文引用的文献

1
All classes of murine IgG antibody mediate macrophage phagocytosis and lysis of erythrocytes.所有类别的小鼠IgG抗体都介导巨噬细胞对红细胞的吞噬作用和裂解作用。
J Immunol. 1980 Nov;125(5):1885-8.
2
A new Fc receptor on mouse macrophages binding IgG3.小鼠巨噬细胞上一种新的结合IgG3的Fc受体。
J Exp Med. 1981 Mar 1;153(3):514-9. doi: 10.1084/jem.153.3.514.
3
Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum.小鼠腺癌755腹水型的免疫控制。IV. 超免疫血清中保护性抗体的特性
J Immunol. 1981 Jun;126(6):2332-6.
4
Fc receptors of mouse cell lines. I. Distinct proteins mediate the IgG subclass-specific Fc binding activities of macrophages.小鼠细胞系的Fc受体。I. 不同蛋白质介导巨噬细胞的IgG亚类特异性Fc结合活性。
J Immunol. 1982 Apr;128(4):1819-24.
5
Structural Aspects and Heterogeneity of Immunoglobulin Fc Receptors.免疫球蛋白Fc受体的结构特征与异质性
Adv Immunol. 1981;31:247-70. doi: 10.1016/s0065-2776(08)60922-0.
6
Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia.卡介苗激活的小鼠巨噬细胞的表面特性。甘露糖特异性内吞作用、Fc受体和抗原F4/80的表达降低伴随着Ia的诱导。
J Exp Med. 1981 Jul 1;154(1):60-76. doi: 10.1084/jem.154.1.60.
7
Role of activated macrophages in antibody-dependent lysis of tumor cells.活化巨噬细胞在肿瘤细胞抗体依赖性裂解中的作用。
J Exp Med. 1980 Jul 1;152(1):183-97. doi: 10.1084/jem.152.1.183.
8
Down-regulation of mannosyl receptor-mediated endocytosis and antigen F4/80 in bacillus Calmette-Guérin-activated mouse macrophages. Role of T lymphocytes and lymphokines.卡介苗激活的小鼠巨噬细胞中甘露糖受体介导的内吞作用及抗原F4/80的下调。T淋巴细胞和淋巴因子的作用。
J Exp Med. 1982 Jun 1;155(6):1623-37. doi: 10.1084/jem.155.6.1623.
9
T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.在对三硝基苯基 - 聚蔗糖的抗体应答中T细胞对免疫球蛋白类别表达的调节。T细胞增强免疫球蛋白类别转换的证据。
J Exp Med. 1982 Mar 1;155(3):884-902. doi: 10.1084/jem.155.3.884.
10
Prostaglandin synthesis by macrophages requires a specific receptor-ligand interaction.巨噬细胞合成前列腺素需要特定的受体-配体相互作用。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4279-82. doi: 10.1073/pnas.77.7.4279.