巨噬细胞活化选择性增强IgG2a的Fc受体表达。
Macrophage activation selectively enhances expression of Fc receptors for IgG2a.
作者信息
Ezekowitz R A, Bampton M, Gordon S
出版信息
J Exp Med. 1983 Feb 1;157(2):807-12. doi: 10.1084/jem.157.2.807.
Abstract
After infection with bacillus Calmette-Guérin, peritoneal macrophages (Mø) display enhanced expression of FcR for both monomeric and complexed IgG2a, but not IgG2b. Isotype specificity of FcR can be reversed on nonactivated Mø by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mø. Selective enhancement of IgG2a FcR by Mø activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems.
摘要
感染卡介苗后，腹腔巨噬细胞（Mø）对单体和复合IgG2a的FcR表达增强，但对IgG2b则不然。FcR的同种型特异性可被免疫淋巴细胞因子在未激活的Mø上逆转，并且IgG2a免疫复合物是激活的Mø中呼吸爆发更有效的触发因素。Mø激活对IgG2a FcR的选择性增强可能解释了同源抗体在某些系统中介导细胞毒性的功效。
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