Towle V L, Moskowitz A, Sokol S, Schwartz B
Invest Ophthalmol Vis Sci. 1983 Feb;24(2):175-83.
In order to determine the optimum stimulus conditions for the detection of optic nerve damage due to glaucoma and ocular hypertension, checkerboard pattern reversal visual evoked potentials (VEPs) were recorded from 20 glaucoma patients, 20 ocular hypertensive patients, and 20 age-matched normals. Two check sizes (12' and 48'), two field sizes (14 degrees and 28 degrees), and two alternation rates (1.9 and 7.5 alt/sec) were used. All subjects had visual acuities of 20/40 or better in each eye and equal pupils of 2 to 5 mm diameter. The largest number of VEP abnormalities were found with large checks (48') reversing at a fast rate (7.5 alt/sec). After correcting for the effects of age, visual acuity, and pupil size, 16 of 30 eyes with glaucomatous visual field defects had abnormally long VEP latencies under this condition (beyond the 99% confidence limit of the normal subjects). Nine of 40 ocular hypertensive eyes also had abnormally long latencies. Increased pattern VEP latency was significantly correlated with both the severity and location of visual field defects and the degree of cupping and pallor of the optic disc. VEP latency was not significantly related to intraocular pressure.
为了确定检测青光眼和高眼压导致的视神经损伤的最佳刺激条件，对20例青光眼患者、20例高眼压患者和20例年龄匹配的正常人进行了棋盘格图案翻转视觉诱发电位（VEP）记录。使用了两种方格大小（12'和48'）、两种视野大小（14度和28度）以及两种翻转频率（1.9和7.5次/秒）。所有受试者每只眼睛的视力均为20/40或更好，瞳孔直径为2至5毫米且等大。在大方格（48'）以快速率（7.5次/秒）翻转时发现的VEP异常数量最多。在校正年龄、视力和瞳孔大小的影响后，在这种情况下，30只患有青光眼性视野缺损的眼睛中有16只的VEP潜伏期异常延长（超出正常受试者的99%置信限）。40只高眼压眼中有9只的潜伏期也异常延长。图形VEP潜伏期增加与视野缺损的严重程度和位置以及视盘的杯凹和苍白程度显著相关。VEP潜伏期与眼压无显著相关性。
