血浆胺氧化酶与精神分裂症的遗传易感性。
Plasma amine oxidase and genetic vulnerability to schizophrenia.
作者信息
Baron M, Asnis L, Gruen R, Levitt M
出版信息
Arch Gen Psychiatry. 1983 Mar;40(3):275-9. doi: 10.1001/archpsyc.1983.01790030045005.
Abstract
Plasma amine oxidase (PAO) activity was studied in 52 chronic schizophrenics, 130 first-degree relatives, and 36 normal control subjects. Enzyme activity was shown to be a heritable and stable characteristic. Age and sex effects were not present. Patients had lower PAO activity than did control subjects, although the difference fell short of statistical significance. Within families, reduced PAO activity was associated with schizophrenia spectrum disorders.
摘要
对52名慢性精神分裂症患者、130名一级亲属和36名正常对照者的血浆胺氧化酶（PAO）活性进行了研究。酶活性被证明是一种可遗传且稳定的特征。不存在年龄和性别影响。患者的PAO活性低于对照者，尽管差异未达到统计学显著性。在家族内部，PAO活性降低与精神分裂症谱系障碍相关。
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