Myers J, Morgan T
Clin Exp Hypertens A. 1983;5(1):99-118. doi: 10.3109/10641968309048813.
Two hundred and one volunteers with no known hypertension and 60 patients with untreated hypertension were entered into a study that compared the effect of two levels of sodium intake on blood pressure. One hundred and fifty-four volunteers and 46 hypertensive patients reached compliance goals, with a urinary sodium excretion on the high sodium diet twice that on the reduced sodium intake. The blood pressure on the high sodium diet was 4.5 +/- 0.5 mmHg (n = 154 p less than 0.001) higher than on the reduced sodium diet in normotensive individuals and was increased by 8.4 +/- 1.5 mmHg (n = 46 p less than 0.001) in hypertensive individuals. In the volunteer group the major rise in blood pressure occurred in people over the age of 50. In the hypertensive patients the alteration in blood pressure was not age dependent. In the younger age groups some individuals had an increase in blood pressure when on the high sodium intake which was outside the spontaneous variations in blood pressure of a control group. This implied that a number of young normotensive individuals were susceptible to this alteration in sodium intake. Changes in sodium intake alter blood pressure in hypertensive people, in normotensive people over 50 and in a small number of younger normotensive people. Overall reduction of sodium intake from 200 - 70 mmol/day would reduce the blood pressure level of the population and would reduce the number of people who have a blood pressure that requires drug therapy.
201名无高血压病史的志愿者和60名未经治疗的高血压患者参与了一项研究，该研究比较了两种钠摄入量水平对血压的影响。154名志愿者和46名高血压患者达到了依从性目标，高钠饮食时的尿钠排泄量是低钠饮食时的两倍。在血压正常的个体中，高钠饮食时的血压比低钠饮食时高4.5±0.5 mmHg（n = 154，p<0.001），在高血压个体中血压升高了8.4±1.5 mmHg（n = 46，p<0.001）。在志愿者组中，血压的主要升高发生在50岁以上的人群中。在高血压患者中，血压变化与年龄无关。在较年轻的年龄组中，一些个体在高钠摄入时血压升高，超出了对照组血压的自然波动范围。这表明一些年轻的血压正常个体对钠摄入量的这种变化敏感。钠摄入量的变化会使高血压患者、50岁以上的血压正常者以及少数较年轻的血压正常者的血压发生改变。将钠摄入量从每天200 - 70 mmol总体减少，将降低人群的血压水平，并减少需要药物治疗的高血压患者数量。
