烟酸对99mTc-PIPIDA肝脏转运的急性影响。

Acute effects of nicotinic acid on hepatic transport of 99mTc-PIPIDA.

作者信息

Shafer R B, Knodell R G, Stanley L N, Elson M K

出版信息

Eur J Nucl Med. 1983;8(1):12-4. doi: 10.1007/BF00263507.

Abstract

Hepatic injury has been associated with nicotinic acid treatment of schizophrenia and hypercholesterolemia. This association was implicated when the liver and biliary tract were not visualized after 99mTc-HIDA in a patient taking 3 g daily of nicotinic acid. We studied hepatic transport of 99mTc-PIPIDA both in vitro in isolated hepatocytes and in vivo in rabbits pretreated with nicotinic acid to further examine this association. Nicotinic acid increased uptake of PIPIDA by isolated hepatocytes and 7 days of nicotinic acid treatment in rabbits produced no abnormalities in hepatic uptake, gallbladder visualization, or biliary excretion of PIPIDA. We conclude that nicotinic acid does not have an inhibitory effect on uptake of biliary imaging agents and actually may be useful in enhancing hepatic imaging in patients with reduced liver function.

摘要

肝损伤与烟酸治疗精神分裂症和高胆固醇血症有关。一名每天服用3克烟酸的患者在接受99mTc-HIDA检查后肝脏和胆道未显影，提示了这种关联。我们在体外分离的肝细胞中以及在经烟酸预处理的兔子体内研究了99mTc-PIPIDA的肝转运，以进一步研究这种关联。烟酸增加了分离肝细胞对PIPIDA的摄取，并且在兔子中进行7天的烟酸治疗后，PIPIDA的肝脏摄取、胆囊显影或胆汁排泄均未出现异常。我们得出结论，烟酸对胆道显像剂的摄取没有抑制作用，实际上可能有助于增强肝功能减退患者的肝脏显像。