Kennedy R C, Ionescu-Matiu I, Sanchez Y, Dreesman G R
Eur J Immunol. 1983 Mar;13(3):232-5. doi: 10.1002/eji.1830130310.
A common idiotype was defined by a rabbit anti-idiotypic antiserum generated against human antibodies to hepatitis B surface antigen (anti-HBs). This idiotype was detected in anti-HBs from eight different individuals who had been previously infected with hepatitis B virus and is referred to as the CHBs idiotype. The CHBs idiotype was also identified in sera from rabbits, mice, guinea pigs, swine, goats and chimpanzees that had been immunized with hepatitis B surface antigen (HBsAg). Expression of the CHBs idiotype in sera from other species was associated with anti-HBs molecules. These results suggested that variable-region genes responsible for the CHBs idiotype have been conserved through long periods of evolution. It was noteworthy that the CHBs idiotype was not detected in the sera of a nonmammalian species, chickens, that had been successfully immunized with HBsAg.
一种常见的独特型由针对人抗乙型肝炎表面抗原（抗-HBs）抗体产生的兔抗独特型抗血清所定义。这种独特型在先前感染过乙型肝炎病毒的8个不同个体的抗-HBs中被检测到，被称为CHBs独特型。在已用乙型肝炎表面抗原（HBsAg）免疫的兔、小鼠、豚鼠、猪、山羊和黑猩猩的血清中也鉴定出了CHBs独特型。其他物种血清中CHBs独特型的表达与抗-HBs分子相关。这些结果表明，负责CHBs独特型的可变区基因在长期进化过程中得以保守。值得注意的是，在已成功用HBsAg免疫的非哺乳动物物种鸡的血清中未检测到CHBs独特型。
