Korec E, Hlozánek I, Stará J, Nĕmecek V
Folia Biol (Praha). 1987;33(2):98-103.
Rabbit and mouse sera containing anti-idiotype antibodies against a monoclonal and against some polyclonal anti-HBsAg antibodies were prepared. The immunoglobulin fractions of these sera induced the formation of anti-HBsAg antibodies when injected into BALB/c mice. The sera of humans repeatedly immunized with human anti-HBsAg antibodies were shown to contain anti-idiotype antibodies capable of eliciting an anti-HBsAg response in BALB/c mice and Syrian hamsters. Such sera may be a potential source of human anti-idiotype vaccine.
制备了含有针对单克隆抗体以及一些多克隆抗-HBsAg抗体的抗独特型抗体的兔血清和鼠血清。当将这些血清的免疫球蛋白组分注射到BALB/c小鼠体内时，可诱导抗-HBsAg抗体的形成。经人抗-HBsAg抗体反复免疫的人的血清显示含有能够在BALB/c小鼠和叙利亚仓鼠中引发抗-HBsAg反应的抗独特型抗体。这类血清可能是人类抗独特型疫苗的一个潜在来源。
