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与人类抗乙型肝炎表面抗原抗体相关的共同独特型决定簇。

Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.

作者信息

Kennedy R C, Dreesman G R

出版信息

J Immunol. 1983 Jan;130(1):385-9.

PMID:6183357
Abstract

Anti-Id antisera generated to purified anti-HBs isolated from two different individuals recognized a common idiotype. This idiotype was detected in purified anti-Hbs preparations from three individuals and also in anti-HBs-positive sera obtained from six hemophilic patients. The ability of both HBsAg and a virus-derived HBsAg native polypeptide to inhibit the idiotype-anti-idiotype reaction suggested that the anti-HBs idiotype was associated with the antibody-combining site.

摘要

从两名不同个体分离出的纯化抗-HBs产生的抗独特型抗血清识别出一种共同的独特型。这种独特型在来自三名个体的纯化抗-HBs制剂中被检测到，也在从六名血友病患者获得的抗-HBs阳性血清中被检测到。HBsAg和一种病毒衍生的HBsAg天然多肽抑制独特型-抗独特型反应的能力表明，抗-HBs独特型与抗体结合位点相关。

相似文献

1
Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.与人类抗乙型肝炎表面抗原抗体相关的共同独特型决定簇。
J Immunol. 1983 Jan;130(1):385-9.
2
Anti-idiotypic humoral and cellular responses to antibody to hepatitis B surface antigen in hepatitis B viral infections.乙型肝炎病毒感染中针对乙型肝炎表面抗原抗体的抗独特型体液和细胞反应。
Clin Exp Immunol. 1988 Sep;73(3):360-5.
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Detection of interspecies idiotypic cross-reactions associated with antibodies to hepatitis B surface antigen.与乙型肝炎表面抗原抗体相关的种间独特型交叉反应的检测
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Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2 alpha) anti-idiotypic antibodies.非内影像（Ab2α）抗独特型抗体在小鼠中诱导抗乙型肝炎表面抗原反应
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Monoclonal 'internal image' anti-idiotypic antibodies of hepatitis B surface antigen.乙肝表面抗原的单克隆“内影像”抗独特型抗体。
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Antigen mimicry by anti-idiotype antibodies that recognize a common anti-hepatitis B surface antigen idiotype.
Adv Exp Med Biol. 1985;185:139-47. doi: 10.1007/978-1-4684-7974-4_9.
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Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies to HBsAg among patients with chronic hepatitis B virus infection.慢性乙型肝炎病毒感染患者中乙肝表面抗原（HBsAg）与异源亚型特异性抗-HBsAg抗体的共存情况。
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Characterization of private and cross-reactive idiotypes associated with human antibodies to hepatitis B surface antigen.与人类抗乙型肝炎表面抗原抗体相关的独特型及交叉反应独特型的鉴定
Int Immunol. 1992 Feb;4(2):135-45. doi: 10.1093/intimm/4.2.135.

引用本文的文献

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Cancer Immunol Immunother. 2004 Nov;53(11):987-94. doi: 10.1007/s00262-004-0547-3. Epub 2004 May 19.
2
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J Exp Med. 1983 Sep 1;158(3):718-30. doi: 10.1084/jem.158.3.718.
3
Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.
增强对乙型肝炎表面抗原的免疫反应。抗独特型抗体的体内给药可诱导表达相似独特型的抗-HBs。
J Exp Med. 1984 Mar 1;159(3):655-65. doi: 10.1084/jem.159.3.655.
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J Clin Invest. 1984 Feb;73(2):342-8. doi: 10.1172/JCI111218.
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Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.一种环状合成肽对常见人类抗乙型肝炎表面抗原独特型的抑制作用。
J Virol. 1983 May;46(2):653-5. doi: 10.1128/JVI.46.2.653-655.1983.
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Production, isolation, and characterization of rabbit anti-idiotypic antibodies directed against human antithyrotrophin receptor antibodies.兔抗人抗促甲状腺素受体抗体独特型抗体的制备、分离及特性鉴定
J Clin Invest. 1984 Aug;74(2):488-95. doi: 10.1172/JCI111446.
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Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue-bound immunoglobulins from lupus patients.狼疮患者肾组织结合免疫球蛋白上交叉反应性抗DNA抗体独特型的检测。
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