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衣原体对外源成纤维细胞干扰素的敏感性差异

Differential susceptibility of chlamydiae to exogenous fibroblast interferon.

作者信息

Byrne G I, Rothermel C D

出版信息

Infect Immun. 1983 Feb;39(2):1004-5. doi: 10.1128/iai.39.2.1004-1005.1983.

Abstract

Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN alpha+ beta) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci (6BC), or C. psittaci (Cal 10). Intracellular development of C. trachomatis was reduced 90% in interferon-treated cells 24 h after infection when compared with controls, whereas C. psittaci growth was not affected in interferon-treated cells.

摘要

将小鼠成纤维细胞(L细胞)与每毫升1000单位的鼠成纤维细胞干扰素(MuIFNα + β)一起孵育5小时,然后用沙眼衣原体(LGV 440)、鹦鹉热衣原体(6BC)或鹦鹉热衣原体(Cal 10)进行感染。与对照相比,感染后24小时,干扰素处理的细胞中沙眼衣原体的细胞内发育减少了90%,而干扰素处理的细胞中鹦鹉热衣原体的生长未受影响。

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本文引用的文献

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Chlamydiae.衣原体
Annu Rev Microbiol. 1980;34:285-309. doi: 10.1146/annurev.mi.34.100180.001441.
3
Inhibition of TRIC agents by virus-induced interferon.病毒诱导的干扰素对TRIC因子的抑制作用
Proc Soc Exp Biol Med. 1966 Jun;122(2):417-21. doi: 10.3181/00379727-122-31150.
7
Induction of interferon by the Bour strain of trachoma in HeLa 229 cells.
Am J Ophthalmol. 1967 May;63(5):Suppl:1110-5. doi: 10.1016/0002-9394(67)94091-3.

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