Reidl U
J Chromatogr. 1983 Feb 11;272(2):325-31. doi: 10.1016/s0378-4347(00)86135-6.
A new method has been developed for the determination of acetylsalicylic acid, salicylic acid, salicyluric acid and gentisic acid in plasma, urine and tissue homogenates by simple extraction with ethyl acetate, evaporation and redissolution and measuring by high-performance liquid chromatography. Linearity, reproducibility and recovery were determined. Experiments were carried out to investigate the decomposition of acetylsalicylic acid in plasma with fluoride at different temperatures. The method has been used for pharmacokinetic experiments and an example is given.
已开发出一种新方法，通过用乙酸乙酯简单萃取、蒸发和再溶解，然后用高效液相色谱法测定血浆、尿液和组织匀浆中的乙酰水杨酸、水杨酸、水杨尿酸和龙胆酸。测定了线性、重现性和回收率。进行实验以研究在不同温度下氟化物存在时血浆中乙酰水杨酸的分解情况。该方法已用于药代动力学实验，并给出了一个实例。
