Bruynzeel D P, van Ketel W G, von Blomberg-van der Flier M, Scheper R J
J Am Acad Dermatol. 1983 Mar;8(3):392-7. doi: 10.1016/s0190-9622(83)70044-7.
Allergens eliciting weak positive reactions were retested to ascertain their reproducibility. Weak positive patch test reactions, concomitant to other weak or strong positive reactions, were retested after 3 weeks in 61 patients. 79 reactions were retested; 35 (44.3%) were negative. Allergens which are marginal irritants, e.g., formaldehyde, often gave weak positive reactions which were lost at retesting. In patients without dermatitis but with several strong positive reactions, lost reactions were frequently encountered, suggesting that strong reactions induced a state of hyperirritability. False positive reactions were often found in the proximity of strong reactions. We attempted to develop a nonspecific irritant (sodium lauryl sulfate) as a hyperirritability marker. A correlation between the score of this test and false positive reactions was not found. It is concluded that weak positive reactions should not be accepted as a proof of sensitization. The allergens eliciting these reactions should be retested at a later date.
对引发弱阳性反应的变应原进行重新检测，以确定其可重复性。61例患者在出现弱阳性斑贴试验反应且伴有其他弱或强阳性反应后3周进行重新检测。共重新检测了79次反应；其中35次（44.3%）为阴性。边缘性刺激物变应原，如甲醛，常产生弱阳性反应，重新检测时这些反应会消失。在无皮炎但有多个强阳性反应的患者中，经常出现反应消失的情况，这表明强反应会诱发一种高敏状态。在强反应附近经常发现假阳性反应。我们试图开发一种非特异性刺激物（月桂醇硫酸酯钠）作为高敏状态的标志物。未发现该试验评分与假阳性反应之间存在相关性。得出的结论是，弱阳性反应不应被视为致敏的证据。引发这些反应的变应原应在之后重新检测。
