Van Steenbrugge G J, Blankenstein M A, Bolt-de Vries J, Romijn J C, Schröder F H, Vihko P
J Urol. 1983 Mar;129(3):630-3. doi: 10.1016/s0022-5347(17)52267-3.
The influence of endocrine manipulation on the tissue concentration of prostatic acid phosphatase (PAP) was studied in the hormone dependent transplantable human prostatic tumor line PC-82. Tumor bearing nude mice were left intact, castrated or treated for a 5-day period with a subcutaneous implant containing testosterone or estradiol. The concentration of PAP in castrated mice was not different from that in the controls. The DNA content of PC-82 tumor tissue obtained from 5-day castrated animals was significantly lower than that of tissue from intact animals. Therefore the concentration of PAP in tissue from castrated mice was significantly elevated when expressed per mg. of DNA (p less than 0.05). Treatment of the mice with testosterone or estradiol did not affect the PAP concentration in the tumor tissue. A significant correlation was observed between the concentration of PAP in the serum and the tumor burden of the mice. Long-term withdrawal of androgens resulted in a decrease of the concentration of PAP in the serum, as well as in a decrease of the tumor burden. The concentration of PAP in the tumor tissue remaining after castration of these animals was not significantly different from that in controls. The present data from the tumor line PC-82 do not support the hypothesis that the concentration of PAP in prostatic tumor tissue is controlled by androgens, but are in agreement with the concept that the level of PAP in plasma is related to the tumor mass.
在内分泌依赖性可移植人前列腺肿瘤细胞系PC - 82中，研究了内分泌调控对前列腺酸性磷酸酶（PAP）组织浓度的影响。将荷瘤裸鼠分为完整组、去势组或用含睾酮或雌二醇的皮下植入物处理5天。去势小鼠中PAP的浓度与对照组无差异。从去势5天的动物获得的PC - 82肿瘤组织的DNA含量显著低于完整动物的组织。因此，当以每毫克DNA表示时，去势小鼠组织中PAP的浓度显著升高（p < 0.05）。用睾酮或雌二醇处理小鼠不影响肿瘤组织中PAP的浓度。观察到血清中PAP的浓度与小鼠的肿瘤负荷之间存在显著相关性。长期去除雄激素导致血清中PAP浓度降低，同时肿瘤负荷也降低。这些动物去势后残留的肿瘤组织中PAP的浓度与对照组无显著差异。来自肿瘤细胞系PC - 82的当前数据不支持前列腺肿瘤组织中PAP浓度受雄激素控制的假说，但与血浆中PAP水平与肿瘤质量相关的概念一致。
