Morozumi P A, Brummer E, Stevens D A
Mycopathologia. 1983 Jan 17;81(1):35-9. doi: 10.1007/BF00443907.
N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) protected against pulmonary blastomycosis when given prophylactically to BALB/c mice. Its desmethyl analogue (DM-MDP) had a similar effect. In C3H/HeJ, the effect was less marked. Early treatment after infection, with MDP and DM-MDP, had a modest effect in C3H/HeJ and BALB/c respectively, whereas late treatment had no effect in any mouse strain. No effect could be demonstrated with challenge sizes producing too lethal a model or minimal lethality, or in DBA/2J or young BALB/c mice. The effects in various strains do not correlate with differing effects on nonspecific immunostimulation in these strains. Immunostimulation with glycopeptides deserves further study in prophylaxis or therapy of fungal infection.
对BALB/c小鼠进行预防性给药时，N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）可预防肺芽生菌病。其去甲基类似物（DM-MDP）也有类似效果。在C3H/HeJ小鼠中，这种效果不太明显。感染后早期用MDP和DM-MDP治疗，在C3H/HeJ和BALB/c小鼠中分别有一定效果，而晚期治疗对任何小鼠品系均无效果。对于产生致死性过高或致死率极低的攻击剂量，或者在DBA/2J或幼年BALB/c小鼠中，均未显示出效果。不同品系中的效果与这些品系中非特异性免疫刺激的不同效果无关。糖肽的免疫刺激在真菌感染的预防或治疗中值得进一步研究。
