合成免疫佐剂胞壁酰二肽增强新生儿对克雷伯菌感染的非特异性免疫力。
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.
作者信息
Parant M, Parant F, Chedid L
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3395-9. doi: 10.1073/pnas.75.7.3395.
Abstract
N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) and certain derivatives that are structural analogs of part of the bacterial peptidoglycan monomer have been shown to be adjuvant active and to enhance the nonspecific immunity of adult mice infected by Klebsiella pneumoniae. In the present study muramyl dipeptide and two other synthetic analogs were found to be active in newborn mice. This activity could be demonstrated after administration by subcutaneous or even by oral route. In contrast to what was observed after treatment by lipopolysaccharide, 8-day-old mice were definitively protected against bacterial challenge by these glycopeptides. Therefore such molecules could have a great value in view of studying and correcting the neonate's unresponsiveness.
摘要
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（胞壁二肽）以及某些作为细菌肽聚糖单体部分结构类似物的衍生物，已被证明具有佐剂活性，并能增强感染肺炎克雷伯菌的成年小鼠的非特异性免疫力。在本研究中，发现胞壁二肽和另外两种合成类似物在新生小鼠中具有活性。这种活性在通过皮下甚至口服途径给药后都可以得到证实。与脂多糖治疗后观察到的情况相反，这些糖肽能明确保护8日龄小鼠免受细菌攻击。因此，鉴于研究和纠正新生儿无反应性，此类分子可能具有重大价值。
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