Gottschalk L A, Welch W D, Weiss J
Psychother Psychosom. 1983;39(1):23-35. doi: 10.1159/000287718.
A summary of the scope and mechanisms of the immune response is given and the hypothesis is put forth that, from the immunologic point of view, infections and neoplasms are the result of deficient recognition or arousal of effective defense systems against a foreign invader. An overview is provided of animal and human natural history, epidemiological, or experimental studies relating psychosocial variables to host defenses against infectious and neoplastic disorders; these studies implicate the involvement and competency of the immune system. An exploratory study is reported examining the relationship of a depressive reaction in 7 human subjects to the immune function of polymorphonuclear neutrophils. The 3 most depressed and/or hostile subjects showed significant inhibition of normal (chemiluminescence) immune response of polymorphonuclear neutrophils as compared to nondepressed healthy subjects. This inhibition of the immune response could not be attributed to the effects of pharmacologic agents, plasma cortisol levels, or differences in circadian rhythm.
本文给出了免疫反应的范围和机制的总结，并提出了一种假说，即从免疫学角度来看，感染和肿瘤是针对外来入侵者的有效防御系统识别不足或激活不足的结果。本文还概述了将心理社会变量与宿主针对感染性和肿瘤性疾病的防御联系起来的动物和人类自然史、流行病学或实验研究；这些研究表明免疫系统参与其中并具备相应功能。本文报告了一项探索性研究，该研究考察了7名人类受试者的抑郁反应与多形核中性粒细胞免疫功能之间的关系。与未患抑郁症的健康受试者相比，3名抑郁程度最高和/或敌意最强的受试者的多形核中性粒细胞正常（化学发光）免疫反应受到显著抑制。这种免疫反应的抑制不能归因于药物作用、血浆皮质醇水平或昼夜节律差异。
