Mitas J A, Mosley C A, Drager A M
South Med J. 1983 Apr;76(4):462-3, 467.
Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities. Six patients had relief of pain within five days of initiation of therapy. One patient had no pain relief despite mood alteration. The relief of pain persisted whether renal function was stable or declining. This form of therapy is safe and as effective in patients with neuropathic pain and mild to moderate renal insufficiency as in patients with normal renal function.
七名患糖尿病10至24年且伴有肾功能不全的患者接受了氟奋乃静和阿米替林治疗，以试图控制四肢的剧痛。六名患者在开始治疗的五天内疼痛得到缓解。一名患者尽管情绪有所改变，但疼痛并未缓解。无论肾功能稳定还是下降，疼痛缓解情况持续存在。这种治疗方式对于患有神经性疼痛和轻至中度肾功能不全的患者而言是安全且有效的，与肾功能正常的患者一样。
